LINNEA®
SCIENTIFIC DATA


Linnea is proud to participate in pre-clinical and clinical studies and scientific events

May 10th 2022


“Total synthesis of (-)-Cannabidiol-C4”


Paola Marzullo, Alice Maiocchi, Giuseppe Paladino, Umberto Ciriello, Leonardo Lo Presti, Daniele Passarella

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2022


“Cannabidiol has a central role in the NF-kB inhibition of a Cannabis sativa L. extract in human keratinocytes”


ZURICH, SWITZERLAND
36th Swiss annual conference for phytotherapy (36. Schweizerische Jahrestagung für Phytotherapie)

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2022


“Cannabis sativa L. can reduce inflammation in human keratinocytes thanks to the inhibitory effect of cannabidiol on the NF-кB pathway”


BASEL, SWITZERLAND
12th IACM conference on Cannabinoids in medicine, 1st SSCM conference on Cannabis in medicine

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August 18th 2021


“Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson’s Disease”


Giuliano, C., Francavilla, M., Ongari, G., Petese, A., Ghezzi, C., Rossini, N., Blandini, F., Cerri, S.

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October 19th 2020


“A PHASE 1 TRIAL OF THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF CANNABIDIOL ADMINISTERED AS SINGLE-DOSE OIL SOLUTION AND SINGLE AND MULTIPLE DOSES OF A SUBLINGUAL WAFER IN HEALTHY VOLUNTEERS”


Hosseini A, McLachlan AJ, Lickliter JD.

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September 29th 2020


“Cannabidiol as the substrate in acid-catalyzed intramolecular cyclization”


Paola Marzullo, Francesca Foschi, Davide Andrea Coppini, Fabiola Fanchini, Lucia Magnani, Selina Rusconi, Marcello Luzzani, Daniele Passarella

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2020


“Neuroprotective effects of cannabidiol in an animal model of Parkinson’s disease”


VIRTUAL EVENT
FENS 2020 Virtual Forum of Neuroscience

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January 24th 2020


“RED CLOVER AND LIFESTYLE CHANGES TO CONTRAST MENOPAUSAL SYMPTOMS IN PREMENOPAUSAL PATIENTS WITH HORMONE‑SENSITIVE BREAST CANCER RECEIVING TAMOXIFEN”


Cristina Ferraris, Barbara Ballestra, Chiara Listorti, Vera Cappelletti, Carolina Reduzzi, Gianfranco P. Scaperrotta, Iolanda Pulice, Eleonora G. A. Ferrari, Secondo Folli, Luigi Mariani, Gabriele Martelli

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June 25th 2019


“COMPARISON OF TWO GINKGO BILOBA L. EXTRACTS ON OXIDATIVE STRESS AND INFLAMMATION MARKERS IN HUMAN ENDOTHELIAL CELLS”


Stefano Piazza, Barbara Pacchetti, Marco Fumagalli, Fabrizia Bonacina, Mario Dell’Agli, Enrico Sangiovanni

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May 7th 2019


“Cannabis sativa L. extract and cannabidiol inhibit in vitro mediators of skin inflammation and wound injury”


Enrico Sangiovanni, Marco Fumagalli, Barbara Pacchetti, Stefano Piazza, Andrea Magnavacca, Saba Khalilpour, Gloria Melzi, Giulia Martinelli, Mario Dell’Agli

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April 25th 2019


“NEUROPROTECTIVE EFFECTS OF LIGNAN 7-HYDROXYMATAIRESINOL (HMR/LIGNAN®) IN A RODENT MODEL OF PARKINSON’S DISEASE”


Claudio Giuliano, Francesca Siani, Liudmila Mus, Cristina Ghezzi, Silvia Cerri, Barbara Pacchetti, Chiara Bigogno, Fabio Blandini

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April 13th 2019


“A Novel Standardized Cannabis sativa L. Extract and Its Constituent Cannabidiol Inhibit Human Polymorphonuclear Leukocyte Functions”


Alex Mabou Tagne, Franca Marino, Massimiliano Legnaro, Alessandra Luini, Barbara Pacchetti, Marco Cosentino

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2019


“Cannabis sativa L. extract reduces inflammatory markers in human fibroblasts and keratinocytes”


INNSBRUCK, AUSTRIA
GA Congress Innsbruck

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2019


“Safety, tolerability and pharmacokinetics of ‘pharmaceutical-grade full spectrum Cannabidiol’ administered as single sublingual wafer and oil solution in healthy volunteers”


LONDON, UK
CT-Cann

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August 11th 2018


“Untargeted rat brain metabolomics after oral administration of a single high dose of cannabidiol”


Cinzia Citti, Federica Palazzoli, Manuela Licata, Antonietta Vilella, Giuseppina Leo, Michele Zoli, Maria Angela Vandelli, Flavio Forni, Barbara Pacchetti, Giuseppe Cannazza

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2018


“Comparison of a Cannabis sativa L. extract and its derivative Cannabidiol on human polymorphonuclear leukocyte function”


VIENNA, AUSTRIA
Cannabis

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2018


“Cannabidiol modulates migration and oxidative metabolism in human polymorphonuclear leukocytes”


LEIDEN, NETHERLANDS
The 28th annual ICRS Symposium on the Cannabinoids

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2018


“The phytocannabinoid Cannabidiol inhibits migration and reactive oxygen species generation in human polymorphonuclear leukocytes”


VIENNA, AUSTRIA
The international annual congress on controversies on Cannabis-based medicines

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2018


“Anti-inflammatory effects of Cannabis sativa L. in human keratinocytes”


SHANGHAI, CHINA
The 66th annual meeting of the society for medicinal plant and natural product research, the 11th Shanghai international conference on traditional Chinese medicine and natural medicine

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November 20th 2017


“Analysis of cannabinoids in commercial hemp seed oil and decarboxylation kinetics studies of cannabidiolic acid (CBDA)”


Cinzia Citti, Barbara Pacchetti, Maria Angela Vandelli, Flavio Forni, Giuseppe Cannazza

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June 4th 2017


“Pharmaceutical and biomedical analysis of cannabinoids: a critical review”


Cinzia Citti, Daniela Braghiroli, Maria Angela Vandelli, Giuseppe Cannazza.

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2017


“Anti-inflammatory activity of Cannabis sativa L. extracts in an in vitro model of skin inflammation”


BASEL, SWITZERLAND
65th annual meeting of the society for medicinal plant and natural products research

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2017


“Molecular fingerprinting of a Cannabis sativa L. extract in medium-chain triglyceride (MCT) oil”


RIMINI, ITALY
Recent developments in pharmaceutical analysis

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December 11th 2016


“EFFECTS OF A STANDARDISED EXTRACT OF TRIFOLIUM PRATENSE (PROMENSIL) AT A DOSAGE OF 80 MG IN THE TREATMENT OF MENOPAUSAL HOT FLUSHES: A SYSTEMATIC REVIEW AND META-ANALYSIS”


SP Myers, V Vigar

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February 5th 2014


“ISOFLAVONE CONTENT AND ESTROGENIC ACTIVITY OF DIFFERENT BATCHES OF RED CLOVER (TRIFOLIUM PRATENSE L.) EXTRACTS: AN IN VITRO STUDY IN MCF-7 CELLS”


Paola Spagnuolo, Emanuela Rasini, Alessandra Luini, Massimiliano Legnaro, Marcello Luzzani, Enrico Casareto, Massimiliano Carreri, Silvano Paracchini, Franca Marino, Marco Cosentino

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December 10th 2013


“PHARMACOKINETICS AND BIOAVAILABILITY OF PLANT LIGNAN 7-HYDROXYMATAIRESINOL AND EFFECTS ON SERUM ENTEROLACTONE AND CLINICAL SYMPTOMS IN POSTMENOPAUSAL WOMEN: A SINGLE- BLINDED, PARALLEL, DOSE-COMPARISON STUDY”


Jay K. Udani MD, Donald J. Brown ND, Maria Olivia C. Tan MS, Mary Hardy MD

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August 26th 2011


“THE EFFECT OF RED CLOVER ISOFLAVONE SUPPLEMENTATION OVER VASOMOTOR AND MENOPAUSAL SYMPTOMS IN POSTMENOPAUSAL WOMEN”


Markus Lipovac, Peter Chedraui, Christine Gruenhut, Anca Gocan, Christine Kurz, Benedikt Neuber, Martin Imhof

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December 11th 2009


“IMMUNOMODULATORY ACTIVITY OF THE LIGNAN 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMR/LIGNAN®) EXTRACTED FROM THE HEARTWOOD OF NORWAY SPRUCE (PICEA ABIES)”


Marco Cosentino, Franca Marino, Ramòna Consuélo Maio, Marco Gioacchino Delle Canne, Marcello Luzzani, Silvano Paracchini, Sergio Lecchini

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March 1st 2008


“RED CLOVER ISOFLAVONES ARE SAFE AND WELL TOLERATED IN WOMEN WITH A FAMILY HISTORY OF BREAST CANCER”


Trevor J Powles, Anthony Howell, D Gareth Evans, Eugene V McCloskey, Sue Ashley, Rosemary Greenhalgh, Jenny Affen, Lesley Ann Flook, Alwynne Tidy

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August 2007


“ESTROGENIC ACTIVITY OF 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMR/LIGNAN®) FROM NORWAY SPRUCE (PICEA ABIES) KNOTS AND OF ITS ACTIVE METABOLITE ENTEROLACTONE IN MCF-7 CELLS”


Marco Cosentino, Franca Marino, Marco Ferrari, Emanuela Rasini, Raffaella Bombelli, Alessandra Luini, Massimiliano Legnaro, Marco Gioacchino Delle Canne, Marcello Luzzani, Francesca Crema, Silvano Paracchini, Sergio Lecchini

LINK

November 2005


“THE EFFECT OF RED CLOVER ISOFLAVONES ON MENOPAUSAL SYMPTOMS, LIPIDS AND VAGINAL CYTOLOGY IN MENOPAUSAL WOMEN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY”


Luis A. Hidalgo, Peter A Chedraui, Nancy Morocho, Susana Ross, Glenda San Miguel

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February 2005


“A THIRTEEN WEEK DIETARY TOXICITY STUDY WITH 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMRLIGNAN) IN RATS”


B Lina, H Korte, L Nyman, M Unkila

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February 24th 2004


“RED CLOVER-DERIVED ISOFLAVONES AND MAMMOGRAPHIC BREAST DENSITY: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL”


Charlotte Atkinson, Ruth ML Warren, Evis Sala, Mitch Dowsett, Alison M Dunning, Catherine S Healey, Shirley Runswick, Nicholas E Day, Sheila A Bingham

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August 2004


“PRENATAL DEVELOPMENTAL TOXICITY STUDY WITH 7-HYDROXYMATAIRESINOL POTASSIUM ACETATE (HMRLIGNAN) IN RATS”


APM Wolterbeek, A Roberts, H Korte, M Unkila, D H Waalkens-Berendsen

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May 2004


“CHEMOPREVENTIVE EFFECTS OF HYDROXYMATAIRESINOL ON UTERINE CARCINOGENESIS IN DONRYU RATS”


Shin-ichi Katsuda, Midori Yoshida, Niina Saarinen, Annika Smeds, Dai Nakae, Risto Santti, Akihiko Maekawa

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August 8th 2003


“THE EFFECTS OF PHYTOESTROGEN ISOFLAVONES ON BONE DENSITY IN WOMEN: A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED TRIAL”


Charlotte Atkinson, Juliet E Compston, Nicholas E Day, Mitch Dowsett, Sheila A Bingham

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April 24th 2003


“ISOFLAVONES REDUCE ARTERIAL STIFFNESS: A PLACEBO-CONTROLLED STUDY IN MEN AND POSTMENOPAUSAL WOMEN”


Helena J. Teede, Barry P. McGrath, Lakmini DeSilva, Marja Cehun, Andriana Fassoulakis, Paul J. Nestel

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August 2002


“ANTIOXIDANT AND ANTITUMOR EFFECTS OF HYDROXYMATAIRESINOL (HM-3000, HMR), A LIGNAN ISOLATED FROM THE KNOTS OF SPRUCE”


Lauri Kangas, Niina Saarinen, Marja Mutanen, Markku Ahotupa, Riikka Hirsinummi, Mikko Unkila, Merja Perälä, Pasi Soininen, Reino Laatikainen, Helena Korte, Risto Santti

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May 16th 2001


“A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL OF ISOFLAVONES IN THE TREATMENT OF CYCLICAL MASTALGIA”


D. M. Ingram, C. Hickling, L. West, L. J. Mahe, P. M. Dunbar

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May 6th 2002


“ISOFLAVONES FROM RED CLOVER (PROMENSIL®) SIGNIFICANTLY REDUCE MENOPAUSAL HOT FLUSH SYMPTOMS COMPARED WITH PLACEBO”


Peter H.M. van de Weijer, Ronald Barentsen

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February 28th 2001


“THE EFFECT OF ISOFLAVONES EXTRACTED FROM RED CLOVER (RIMOSTIL) ON LIPID AND BONE METABOLISM”


Phillip B. Clifton-Bligh, Rodney J. Baber, Greg R. Fulcher, Maria-Liza Nery, Terry Moreton

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October 21st 1999


“The effects of isoflavones derived from red clover on vasomotor symptoms and endometrial thickness”


L.B. Nachtigall, L. La Grega, W.W. Lee, R. Fenichel, L. Nachtigall

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December 15th 1998


“Isoflavones from red clover improve systemicarterial compliance but not plasma lipids in menopausal women”


Paul J. Nestel, Sylvia Pomeroy, Sally Kay, Paul Komesaroff, Julie Behrsing, James D. Cameron, Leanne West

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Education, Community and Thought Leadership


Linnea goes beyond manufacturing to support our customers, connect with the community, and educate worldwide about the potential therapeutic benefits of our ingredients

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